Micronutrients: nutrients and vitamins supplementation

Micronutrients are essential nutrients required by the human body in small quantities for optimal health and functioning. They include vitamins, minerals, and trace elements. Many diseases are linked to deficiencies in one or several micronutrients, a diet insufficient in a particular element or molecule can hinder the body in many ways.

Finding the correct supplement and fixing a deficiency is trickier than it sounds.

Key information about micronutrients and supplements

  • Micronutrients are essential for the proper functioning of the body, including resource management, cellular repair, and DNA maintenance, all of which are crucial for health span and longevity.
  • Deficiencies in micronutrients can be reliably tested for, and the results may provide valuable insights into the health problems experienced by an individual, allowing targeted interventions to address specific deficiencies.
  • Supplementation could be a viable method of correcting imbalances and addressing insufficiencies in micronutrient levels, helping to restore optimal health and function.
  • Supplementation of vitamins and minerals is not straightforward, as many forms of supplementation require specific conditions to be effective and to achieve desired results, emphasizing the importance of informed supplementation strategies and professional guidance when addressing nutrient deficiencies.

A diverse array of micronutrients, encompassing vitamins and minerals like vitamins A, C, D, E, and K, calcium, iron, magnesium, and zinc, interact synergistically to support a wide range of biochemical processes in the body, underscoring the importance of consuming a varied diet, adequate sleep, plentiful physical activity and avoidance of pollutants and stress to ensure overall health and vitality.

A supplement, as you can guess from the meaning of the word is an addition to an already existing diet regimen. So before you try to find a supplement to fix your problems, investing in a good balanced diet should be considered first.

Macronutrients vs micronutrients

Macronutrients and micronutrients are two essential categories of nutrients crucial for overall health and well-being.

Macronutrients

Macronutrients, including carbohydrates, proteins, and fats, are needed in larger quantities to provide the body with energy for various metabolic processes. Carbohydrates serve as the primary energy source, proteins are essential for tissue repair and immune function, and fats play roles in energy storage and vitamin absorption. While macronutrients are primarily about energy, they also contribute to other physiological processes beyond energy production.

Micronutrients

micronutrients encompass vitamins and minerals required in smaller amounts but are equally vital for supporting numerous biochemical reactions and functions in the body. These micronutrients act as cofactors or coenzymes in enzymatic reactions, regulate gene expression, and contribute to immune function, bone health, and many other processes. Despite their smaller quantities, deficiencies in micronutrients can lead to significant health issues, highlighting their critical importance alongside macronutrients for maintaining optimal health and well-being.

Read on below.

Vitamins overview

Vitamins are micronutrients that are essential organic compounds that are required by the human body in small amounts to maintain normal physiological functions.

Vitamins cannot be produced by the body in sufficient quantities and must therefore be obtained from the diet or through supplements.

Top 5 Vitamins We Most Likely to Need as Supplements

The most common supplemented vitamins are:

  • Vitamin D
  • Vitamin B6
  • Vitamin B9 (folate)
  • Vitamin B12
  • Vitamin C.

We need all Vitamins, but the supplementation to be effective a correct form of a vitamin, along with a correct way to take it as well as other considerations have to be taken into account. Gulping a bunch of vitamins may help to reduce deficiency but a more holistic approach is required to fix long-term problems associated with vitamin deficiencies in a safe manner.


Vitamin D

Vitamin D is crucial for longevity as it plays a key role in supporting bone health, immune function, and overall well-being, with adequate levels linked to reduced risk of chronic diseases and enhanced longevity.

Deficiency rate

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Up to 41.6% of people in the US and half of the population globally are deficient in Vitamin D.

Insufficient dietary intake

%
Up to 95% of people in the USA are thought to consume less than EAR of 10 mcg (400 IU) of Vitamin D from food and beverages.

Source: Sun vs Dietary intake

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We can get 80% of Vitamin D from exposure of our skin to the sun, which is tricky in colder months.

Vitamin B6 (pyridoxine)

Vitamin B6 is vital for longevity as it supports brain health, neurotransmitter synthesis, and immune function, contributing to overall well-being and longevity.

Deficiency rate

%
Up to 10% of people in the US and a bit more population globally are deficient in Vitamin B6. Pregnant and breastfeeding women are more likely to experience deficiency.

Insufficient dietary intake

%
Up to 25% of people in the USA are thought to consume less than RDA of 1.2/1.3mg
(female/male) Vitamin B6 from food and beverages,

Pregnancy and breastfeeding

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Suggested increased intake of 1.9/2.0mg (175%) of Vitamin B6 is RDA for pregnant and lactating females, supplements are often used.

Vitamin B9 (folate)

Vitamin B9, also known as folate, is vital for longevity as it supports DNA synthesis, cell division, and red blood cell formation, playing a crucial role in overall health and disease prevention throughout life.

Deficiency rate

%
Up to 8% of people in the US and a bit more population globally are deficient in Vitamin B9. Pregnant and breastfeeding women are more likely to experience deficiency.

Insufficient dietary intake

%
Approximately 19% of people in the USA and Europe are thought to consume less than RDA of 400mcg of Vitamin B9 from food and beverages,

Pregnancy and breastfeeding

%
Suggested increased intake of 600mcg (150%) of
Vitamin B6 is RDA for pregnant and lactating females, supplements are often used.

Vitamin B12 (cobalamin)

Vitamin B12 is crucial for longevity as it plays a key role in DNA synthesis, nerve function, and red blood cell formation, supporting overall health and vitality into later years.

Deficiency rate

%
Up to 10% of people over the age of 75 are deficient in Vitamin B9. Pregnant and breastfeeding women are more likely to experience deficiency.

Vegans and vegetarians at risk

%
Analysis showed high deficiency rates among specific populations of vegetarians and vegans: 62% among pregnant women, between 25% and almost 86% among children, 21–41% among adolescents and 11–90% among the elderly.

Pregnancy and breastfeeding

%
In normal pregnancy, B12 levels fall by 30% by the third trimester of pregnancy. Supplementation is often recommended.

Vitamin C

Vitamin C is essential for longevity as it acts as a powerful antioxidant, and supports immune function, collagen synthesis, and overall tissue repair, contributing to optimal health and resilience against age-related diseases.

Deficiency rate

%
Up to 10% of people over the age of 75 are deficient in Vitamin B9. Pregnant and breastfeeding women are more likely to experience deficiency.

Insufficient intake

%
About 23% of the population in the West are thought to not get enough of Vitamin C in their diet, often resorting to supplements.

Pregnancy and breastfeeding

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In normal pregnancy, Vitamin C intake should be increased by about 25%, and it should almost be doubled during lactation. Supplementation is often recommended.

Honorable mentions

The following vitamins are important but we are often able to get enough of them through diet so they are less popular as supplements.

  • Vitamin A: important for vision, immune function, and cell growth and differentiation.
  • Vitamin B1 (thiamine): necessary for energy production and proper functioning of the nervous system.
  • Vitamin B2 (riboflavin): plays a role in energy metabolism and antioxidant defense.
  • Vitamin B3 (niacin):  helps keep your nervous system, digestive system, and skin healthy.
  • Vitamin B5 (pantothenic acid): involved in energy metabolism and hormone synthesis.
  • Vitamin B7 (biotin): important for metabolism and maintaining healthy skin, hair, and nails.
  • Vitamin E: a potent antioxidant that helps protect against oxidative stress and supports healthy skin and immune function.
  • Vitamin K: important for blood clotting and bone health.

Each vitamin has a specific role in the body and is required for different physiological functions, including energy production, immune function, vision, growth and development, and many others. A deficiency in any vitamin can lead to a range of health problems, depending on the vitamin involved, and can result in a range of conditions such as scurvy, night blindness, anemia, and others.

Multivitamin packs

Multivitamins are popular. Are they effective though?

Multivitamins/mineral supplements often appear to offer a convenient solution, boasting a comprehensive array of vitamins and minerals in a single capsule, but in reality, they may not live up to their promises.

While they may seem like an all-in-one solution, multivitamins often blend various forms of vitamins and minerals, which may not be the most bioavailable or effective. Often the manufacturing process may prioritize cost and convenience over quality, resulting in the inclusion of cheaper, less effective forms of nutrients.

This can make it challenging to ascertain the actual content and potency of the vitamins and minerals within each capsule, raising questions about their efficacy and potential health benefits.

While they may provide some supplemental support for individuals with specific nutrient deficiencies or dietary gaps, multivitamins and mineral packs are not that popular among medical professionals.

Understanding the different forms and sources of vitamins and minerals, as well as assessing individual nutritional needs and potential interactions with medications or existing health conditions, is essential for optimizing the effectiveness and safety of multivitamin supplementation.

Minerals overview

Minerals are inorganic substances that are essential for the human body to maintain normal physiological functions. Some minerals we need for energy balance and in particular, electrolytes.

Minerals by themselves overlap or are electrolytes, but it is worth exploring electrolytes separately.

Unlike vitamins, minerals cannot be synthesized by the body and must be obtained from diet or supplements.

Minerals on this list should all be obtained through diet or supplementation because of their importance, a deficiency in one mineral may lead to significant deterioration of health in the short-term, as symptoms present themselves, but also carry long-term problems.

Obtaining adequate levels of vitamins and minerals through a balanced and nutritious diet (and/or supplementation) is what allows us to maintain homeostasis at a functional level leading to extended health span and prolonged lifespan.

  • Calcium: essential for bone health, muscle function, and nerve transmission.
  • Chromium: involved in carbohydrate and lipid metabolism and may help regulate blood sugar levels.
  • Copper: important for iron metabolism, connective tissue formation, and immune function.
  • Iodine: necessary for thyroid hormone production and regulating metabolic rate.
  • Iron: critical for oxygen transport in the blood and immune function.
  • Magnesium: involved in over 300 enzymatic reactions in the body and necessary for proper muscle and nerve function.
  • Manganese: important for bone health, carbohydrate and lipid metabolism, and antioxidant defense.
  • Phosphorus: necessary for bone health and energy metabolism.
  • Potassium: critical for fluid balance, nerve transmission, and muscle function.
  • Selenium: a potent antioxidant that supports immune function and thyroid health.
  • Sodium: important for fluid balance and nerve transmission.
  • Zinc: involved in immune function, wound healing, and protein synthesis.

Deficiencies in certain minerals can lead to a range of health problems, depending on the mineral involved. For example, iron deficiency can lead to anemia, while calcium deficiency can lead to weakened bones and osteoporosis. On the other hand, excessive intake of certain minerals can also lead to toxicity and health problems.

Top 5 Minerals We Most Likely to Need as Supplements

There is a lot of evidence that deficiencies in these minerals are responsible for a host of health problems, some of those problems present noticeable symptoms and interfere with everyday activities.

Magnesium

Magnesium is crucial for healthspan as it supports cardiovascular function, bone health, muscle relaxation, and energy metabolism, contributing to overall longevity and well-being.

Magnesium is essential for cellular function, serving as a cofactor for numerous enzymatic reactions involved in energy production, DNA synthesis, and protein synthesis, which are vital for maintaining cellular health and longevity.

%
Zinc Deficiency is present in approximately 17% of people.

Magnesium deficiency is associated with muscle cramps, fatigue, cardiovascular issues, impaired nerve function, and decreased bone density.

Zinc

Zinc is essential for healthspan and longevity as it supports immune function, DNA synthesis, wound healing, and reproductive health.

Zinc is essential for cellular function as it plays a key role in DNA synthesis, immune response, and antioxidant defense, supporting overall cellular health and longevity.

%
Zinc Deficiency is present in approximately 17% of people.

Zinc deficiency is associated with impaired immune function, delayed wound healing, growth retardation, and increased susceptibility to infections.

Iodine

Iodine is crucial for healthspan as it supports thyroid hormone production, which regulates metabolism, energy expenditure, and growth, contributing to overall longevity and vitality.

Iodine plays a vital role in cellular function by facilitating thyroid hormone synthesis and regulating gene expression, ensuring optimal cellular metabolism and function throughout the body.

%
Iodine Deficiency is present in approximately 29% of people.

Iodine deficiency is associated with thyroid disorders, cognitive impairment, goiter formation, and developmental abnormalities, highlighting its critical role in overall health and well-being.

Selenium

Selenium is important for healthspan as it acts as a powerful antioxidant, supporting immune function, thyroid health, and DNA repair mechanisms, which are essential for longevity and overall well-being.

Selenium plays a critical role in cellular function by participating in enzyme activities involved in antioxidant defense, thyroid hormone metabolism, and DNA synthesis, ensuring proper cellular function and resilience against age-related damage.

%
Selenium Deficiency is present in approximately 19% of people.

Selenium deficiency can increase the risk of thyroid disorders, compromised immune function, oxidative stress, and cardiovascular disease.

Iron

Iron is important for healthspan as it is essential for oxygen transport, energy production, and DNA synthesis, supporting overall vitality and longevity.

Iron plays a crucial role in cellular function by serving as a cofactor for enzymes involved in oxidative phosphorylation, electron transport, and DNA replication, ensuring optimal cellular metabolism and function throughout the body.

%
Iron Deficiency is present in approximately 9% of people.

Iron deficiency can increase the risk of anemia, fatigue, impaired cognitive function, and compromised immune response.

Honorable mentions

Besides magnesium, zinc, iodine, selenium, and iron other minerals deserve a mention, as they play a role in our health. However, deficiencies in them are rarer.

  • Potassium: Regulates fluid balance, nerve transmission, and muscle function.
  • Calcium: Critical for bone health, muscle contraction, and nerve function.
  • Sodium: Regulates fluid balance, blood pressure, and nerve transmission.
  • Phosphorus: Important for bone health, energy metabolism, and DNA synthesis.
  • Chromium: Supports insulin function and glucose metabolism.
  • Manganese: Necessary for bone formation, antioxidant defense, and metabolism.
  • Copper: Facilitates iron absorption, collagen synthesis, and antioxidant function.
  • Fluoride: Strengthens tooth enamel and helps prevent dental decay.
  • Molybdenum: Assists in enzyme function and metabolism of sulfur-containing amino acids.
  • Chloride: Helps maintain fluid balance and is involved in digestion and nerve function.
  • Cobalt: Essential component of vitamin B12, necessary for red blood cell production and neurological function.

Deficiencies in these minerals present symptoms that are better investigated and researched by a trained medical professional. Most clinics provide tests to look for deficiencies in these and other minerals and vitamins, don’t be shy, invest into your health and get some tests done.

Other micronutrients

Other micronutrients that can be supplemented include:

  • Omega-3 fatty acids: important for brain and heart health.
  • Coenzyme Q10 (CoQ10): involved in energy production and antioxidant defense.
  • Probiotics: beneficial bacteria that support gut health and immune function.
  • Prebiotics: fiber-like compounds that feed the beneficial bacteria in the gut.

There are several compounds that have been studied for their potential to improve longevity in animals and humans. These still require a lot of research but what we know so far about them is promising

  1. Nicotinamide Mononucleotide (NMN): NMN is a molecule that is involved in the production of NAD+, a coenzyme that plays a critical role in energy metabolism and cellular aging. NMN supplements have been shown to increase NAD+ levels in animals and may have potential anti-aging effects.
  2. Resveratrol: Resveratrol is a polyphenol compound found in grapes, berries, and other plants. It has been shown to activate sirtuins, a group of proteins that play a role in regulating cellular aging and stress response. Resveratrol supplements have been shown to extend lifespan in animal studies, although the evidence in humans is limited.
  3. Sulforaphane: Sulforaphane is a compound found in cruciferous vegetables such as broccoli, kale, and cauliflower. It has been shown to activate Nrf2, a protein that plays a role in regulating antioxidant defense and cellular stress response. Sulforaphane supplements have been shown to improve markers of health and reduce inflammation in some studies.
  4. Metformin: Metformin is a medication commonly used to treat type 2 diabetes. It has been shown to activate AMPK, a protein that plays a role in regulating energy metabolism and cellular aging. Some studies have suggested that metformin may have potential anti-aging effects and could extend lifespan in animals.
  5. Rapamycin: Rapamycin is a medication used to prevent rejection in organ transplant recipients. It has been shown to inhibit the mTOR pathway, a signaling pathway that plays a role in regulating cellular growth and aging. Rapamycin supplements have been shown to extend lifespan in animal studies, although the evidence in humans is limited.

It’s important to note that while these compounds have shown promise in animal studies, their effects in humans are still being studied and their long-term safety is not yet fully understood. Studying longevity in particular is It’s always recommended to consult with a healthcare professional before starting any new supplement or medication.